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Critical Thinking in Critical Care Medicine


NICE-SUGAR study-Intensive Blood Glucose control in an ICU might be associated with increased mortality.
Find the original article here https://www.nejm.org/doi/0full/10.1056/NEJMoa0810625 Author: Peter Ryu Tofts, MD Editor: Martin M....

Peter Tofts, MD
Feb 144 min read
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BICAR-ICU trial: in a subgroup with severe acidemia and severe Acute Kidney Injury a bicarbonate infusion reduces need for renal replacement therapy and potentially mortality at 28 days.
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre,...

David Goldenberg, DO
Jan 24 min read
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Leuven I trial - Intensive Blood Glucose control in a Cardiovascular and Surgical ICU is associated with a decrease in mortality and improved secondary outcomes.
Author: Peter Tofts, MD; Edited: Martin Cearras, MD Find the original article here! Intensive Insulin Therapy in Critically Ill Patients...
Martin Cearras, MD
Dec 15, 20242 min read
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STARRT - AKI trial. Harm and unnecessary Renal Replacement Therapy (RRT) when RRT is started early in the ICU.
Critical Appraisal of the Starrt - AKI trial for early renal replacement in the ICU

Peter Tofts, MD
Oct 22, 20243 min read
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Clovers Trial:
Find the original article below! Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
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Classic Trial
Standard vs Restrictive Fluid Administration Restriction of Intravenous Fluid in ICU Patients with Septic Shock | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
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Acorn Trial
Cefepime vs Piperacillin-Tazobactam in adults hospitalized with acute infections Find the original article! Cefepime vs...
Martin Cearras, MD
Oct 16, 20242 min read
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Fresh Trial
Find the original article here!  Fluid Response Evaluation in Sepsis Hypotension and Shock - CHEST ( chestnet.org ) Summary: The “Fresh...
Martin Cearras, MD
Oct 16, 20243 min read
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