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Evidence Based Medicine Concepts

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How to look at a body of evidence instead of just one result.

Forest Plots and result consistency

Basic EBM, Systematic Reviews, Uncertainty, Confidence Intervals

The Diagnostician's Best Friend

Likelihood Ratios

Basic EBM, Interactive, Diagnosis

Likelihood ratio concept page

Sorry, this drug doesn't work on Geminis.

Subgroup Analysis

subgroup analysis, Advanced EBM Concept, Primary outcome, Bias

That is not my mortality - He didn't even go to the OR!

Intention to treat analysis

Basic EBM, RCT

When, who and what?

Blinding

Basic EBM, RCT

Are they hiding the negative papers in a drawer somewhere?

Funnel Plots and publication bias.

Advanced EBM Concept, Systematic Reviews, Bias

Funnel plot description

Why does it matter clinically?

What is Power?

Advanced EBM Concept, Type II error, Study Design, Interactive

How a perceived benefit can be harmful down the road

Stopping trials early

Advanced EBM Concept, Type II error, Type I error

How much is too much?

Loss to follow up

Basic EBM, Loss to follow up, RCT, Uncertainty, Bias

Useful tool or potentially misleading?

Composite outcomes.

Basic EBM, Composite Outcomes

TIME trial, Syntax trial. Composite outcomes.

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