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Evidence Based Medicine Concepts

Stopping trials early

How a perceived benefit can be harmful down the road

Intention to treat analysis:

That is not my complication! We never touched the patient!

Loss to follow up

How much is too much?

Blinding

When, who and what?

TIME trial, Syntax trial. Composite outcomes.

Composite outcomes.

Useful tool or potentially misleading results.

Not all positive outcomes are created equal!

Beware of the trials with multiple secondary or tertiary outcomes.

Are my results robust or fragile?

Fragility index

Win Ratio vs Composite Outcomes

The Rise of the Win Ratio.

Is Time Up for the Traditional Composite Outcome Approach?

Randomized trials vs. Observational studies

Why do EBP people keep insisting on Randomization? I can already see that my device works!

Understanding how randomized trials are superior to observational studies

Throwback to picking teams for dodgeball...

Let's talk Allocation Concealment and Selection Bias.

Outcomes in Journal Articles

How to avoid under or over-estimating effects on our patients, when they are shown in different ways.

Study Design... Why would that matter?!

Understanding validity and risk of bias in published journal articles.

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