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Trach collar vs pressure support for ventilator liberation
Should we use trach collar or pressure support for weaning tracheostomy patients.
Martin Cearras, MD
5h0 min read
Early suspicion-based antifungals in Acute-on-Chronic Liver Failure.
Early empirical antifungals in ACLF patients show a surprisingly strong survival benefit at 28 days.
Martin Cearras, MD
Oct 60 min read
ROSE trial - Early Neuromuscular Blockade in ARDS
In ARDS, while following ARMA trial ventilator management, adding paralyzing agents does not improve survival.
Martin Cearras, MD
Oct 12 min read
Esmolol for Heart Rate Control in Septic Shock
Lifesaving esmolol?
Martin Cearras, MD
Sep 231 min read
VASST Trial: Vasopressin use in Septic Shock - subgroup analysis results should not change practice.
VASST trial, showing vasopressin added to levophed does not improve outcomes or have more harm.
Martin Cearras, MD
Sep 70 min read
PROSEVA trial - to prone or not to prone.
Prone positioning in the ICU improves survival in severe ARDS
Martin Cearras, MD
Sep 30 min read
Understanding Blood Glucose Control in the ICU: A Critical Review
Leuven II trial, strict normalization of blood glucose in medical intensive care units
Peter Tofts, MD
Feb 34 min read
Sodium Bicarbonate for Severe Metabolic Acidemia and Acute Kidney Injury: Insights from the BICARICU-2 Trial
This trial is a follow up to the BICARICU trial which used of sodium bicarbonate in critically ill patients with metabolic acidemia. Primary outcome of mortality was not different; however, renal replacement need was again lower in the intervention group with a NNT of 7.
Martin Cearras, MD
Dec 16, 20253 min read
NICE-SUGAR study-Intensive Blood Glucose control in an ICU might be associated with increased mortality.
Find the original article here https://www.nejm.org/doi/0full/10.1056/NEJMoa0810625 Author: Peter Ryu Tofts, MD Editor: Martin M....
Peter Tofts, MD
Feb 14, 20254 min read
BICAR-ICU trial: in a subgroup with severe acidemia and severe Acute Kidney Injury a bicarbonate infusion reduces need for renal replacement therapy and potentially mortality at 28 days.
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre,...
David Goldenberg, DO
Jan 2, 20254 min read
Leuven I trial - Intensive Blood Glucose control in a Cardiovascular and Surgical ICU is associated with a decrease in mortality and improved secondary outcomes.
Author: Peter Tofts, MD; Edited: Martin Cearras, MD Find the original article here! Intensive Insulin Therapy in Critically Ill Patients...
Martin Cearras, MD
Dec 15, 20242 min read
STARRT - AKI trial. Harm and unnecessary Renal Replacement Therapy (RRT) when RRT is started early in the ICU.
Critical Appraisal of the Starrt - AKI trial for early renal replacement in the ICU
Peter Tofts, MD
Oct 22, 20243 min read
Clovers Trial:
Find the original article below! Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
Classic Trial
Standard vs Restrictive Fluid Administration Restriction of Intravenous Fluid in ICU Patients with Septic Shock | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
Acorn Trial
Cefepime vs Piperacillin-Tazobactam in adults hospitalized with acute infections Find the original article! Cefepime vs...
Martin Cearras, MD
Oct 16, 20242 min read
Fresh Trial
Find the original article here! Fluid Response Evaluation in Sepsis Hypotension and Shock - CHEST ( chestnet.org ) Summary: The “Fresh...
Martin Cearras, MD
Oct 16, 20243 min read
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