top of page
Critical Thinking in Critical Care Medicine
Leuven II trial- Intensive Insulin Therapy in the Medical ICU significantly reduced morbidity but not mortality.
Leuven II trial, strict normalization of blood glucose in medical intensive care units
Peter Tofts, MD
1 day ago3 min read
BICARICU-2: Sodium Bicarbonate reduces need for renal replacement but does not change mortality.
This trial is a follow up to the BICARICU trial which used of sodium bicarbonate in critically ill patients with metabolic acidemia. Primary outcome of mortality was not different; however, renal replacement need was again lower in the intervention group with a NNT of 7.
Martin Cearras, MD
Dec 16, 20252 min read
NICE-SUGAR study-Intensive Blood Glucose control in an ICU might be associated with increased mortality.
Find the original article here https://www.nejm.org/doi/0full/10.1056/NEJMoa0810625 Author: Peter Ryu Tofts, MD Editor: Martin M....
Peter Tofts, MD
Feb 14, 20254 min read
BICAR-ICU trial: in a subgroup with severe acidemia and severe Acute Kidney Injury a bicarbonate infusion reduces need for renal replacement therapy and potentially mortality at 28 days.
Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre,...
David Goldenberg, DO
Jan 2, 20254 min read
Leuven I trial - Intensive Blood Glucose control in a Cardiovascular and Surgical ICU is associated with a decrease in mortality and improved secondary outcomes.
Author: Peter Tofts, MD; Edited: Martin Cearras, MD Find the original article here! Intensive Insulin Therapy in Critically Ill Patients...
Martin Cearras, MD
Dec 15, 20242 min read
STARRT - AKI trial. Harm and unnecessary Renal Replacement Therapy (RRT) when RRT is started early in the ICU.
Critical Appraisal of the Starrt - AKI trial for early renal replacement in the ICU
Peter Tofts, MD
Oct 22, 20243 min read
Clovers Trial:
Find the original article below! Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
Classic Trial
Standard vs Restrictive Fluid Administration Restriction of Intravenous Fluid in ICU Patients with Septic Shock | New England Journal of...
Martin Cearras, MD
Oct 16, 20242 min read
Acorn Trial
Cefepime vs Piperacillin-Tazobactam in adults hospitalized with acute infections Find the original article! Cefepime vs...
Martin Cearras, MD
Oct 16, 20242 min read
Fresh Trial
Find the original article here! Fluid Response Evaluation in Sepsis Hypotension and Shock - CHEST ( chestnet.org ) Summary: The “Fresh...
Martin Cearras, MD
Oct 16, 20243 min read
bottom of page